Chronic Traumatic Encephalopathy
Clinical presentation of chronic traumatic encephalopathy (2013)
Objective: The goal of this study was to examine the clinical presentation of chronic traumatic encephalopathy (CTE) in neuropathologically confirmed cases. Methods: Thirty-six adult male subjects were selected from all cases of neuropathologically confirmed CTE at the Boston University Center for the Study of Traumatic Encephalopathy brain bank. Subjects were all athletes, had no comorbid neurodegenerative or motor neuron disease, and had next-of-kin informants to provide retrospective reports of the subjects’ histories and clinical presentations. These interviews were conducted blind to the subjects’ neuropathologic findings. Results: A triad of cognitive, behavioral, and mood impairments was common overall, with cognitive deficits reported for almost all subjects. Three subjects were asymptomatic at the time of death. Consistent with earlier case reports of boxers, 2 relatively distinct clinical presentations emerged, with one group whose initial features developed at a younger age and involved behavioral and/or mood disturbance (n 5 22), and another group whose initial presentation developed at an older age and involved cognitive impairment (n 5 11). Conclusions: This suggests there are 2 major clinical presentations of CTE, one a behavior/mood variant and the other a cognitive variant. Stern, R. A., Daneshvar, D. H., Baugh, C. M., Seichepine, D. R., Montenigro, P. H., Riley, D. O., & ... McKee, A. C. (2013) Neurology,81(13), 1122-1129.
The Impact of Concussions in Youth and College Sports: Christopher Nowinski
Chris Nowinski, former Harvard athlete, founded Sports Legacy Institute. This Boston based organization seeks to educate the public about the dangers of concussions and the long-term effects of multiple concussions. In this video, Chris Nowinski shares his knowledge about concussion prevention and management to students and faculty at Williams College. https://www.youtube.com/watch?v=mhksd34WwYQ. For more information about the Boston Chronic Traumatic Encephalopathy Center: http://www.bu.edu/cte/
- Improving the memory sections of the Standardized Assessment of Concussion using item analysis [McElhiney, D., Kang, M., Starkey, C., & Ragan, B. (2014), Measurement In Physical Education And Exercise Science, 18(2), 123-134. doi:10.1080/1091367X.2013.866558]
- The neuropsychological outcomes of concussion: A systematic review of meta-analyses on the cognitive sequelae of mild traumatic brain injury[Karr, J. E., Areshenkoff, C. N., & Garcia-Barrera, M. A. (2014), Neuropsychology, 28(3), 321-336. doi:10.1037/neu0000037]